Deciphering the complex roles of leucine-rich repeat receptor kinases (LRR-RKs) in plant signal transduction

Leucine-rich repeat receptor kinases (LRR-RKs) are essential receptor protein kinases in plants that are the key to signal perception and responses and central to regulating plant growth, development, and defense. Despite extensive research on the LRR-RK family, gaps persist in our understanding of their ligand recognition and activation mechanisms, interactions with co-receptor, signal transduction pathways, and biochemical and molecular regulation. Researchers have made significant advances in understanding the critical roles of LRR-RKs in plant growth and development, signal transduction, and stress responses. Here, we first summarized the gene expression levels of LRR-RKs in plants. We then reviewed the conservation and evolutionary relationships of these genes across different species. We also investigated the molecular mechanisms underlying the variations in LRR-RK signaling under different environmental conditions. Finally, we provide a comprehensive summary of how abiotic and biotic stresses modulate LRR-RK signaling pathways in plants.