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Precision peptide disruptors: The next generation of targeted therapeutics in oncology

Bria O'Gorman1, Sean F Cooke1, Connor M Blair1

  • 1College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

Cellular Signalling
|April 3, 2025
PubMed

Insights

Peptide disruptors are emerging as a powerful tool for treating difficult cancers by targeting protein interactions. These next-generation therapies are key to advancing precision medicine for improved patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Cancer involves pathologically remodelled protein-protein interaction networks.
  • Targeting these networks offers a promising therapeutic strategy for recalcitrant cancers.

Purpose of the Study:

  • To review the landscape of peptide disruptors in oncology.
  • To highlight their role in precision medicine and as next-generation targeted therapeutics.

Main Methods:

  • Literature review of pre-clinical and clinical-stage peptide disruptors in cancer.
  • Analysis of key clinical examples demonstrating impact.

Main Results:

  • Peptide disruptors are a clinically attractive approach for treating difficult cancers.
  • Several peptide disruptors are making a significant impact in patient treatment.

Conclusions:

  • Peptide disruptors play a key role in precision medicine.
  • They represent a next-generation targeted therapeutic strategy for oncology.
Keywords:
OncologyPeptide disruptorsPrecision medicineProtein-protein interactions

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