Endocrine disrupters affect the immune system of fish: The example of the European seabass

An organism's fitness critically relies on its immune system to provide protection against parasites and pathogens. The immune system has reached its highest complexity in vertebrates, combining the highly specific adaptive with the non-specific innate immunity. In vertebrates, a complex system of steroid hormones regulates major physiological functions comprising energy metabolism, growth, reproduction and immune system performance. This allows the organism to allocate available energy according to life-history traits and environmental conditions, thus maintaining homeostasis and survival of the individual and of the population. Immune system activation must take into account the developmental stage and the nutritional state of the organism. It should respond adequately to different pathogens, but should not overperform or consume all resources for other physiological functions. This important trade-off between immunity and reproduction is balanced by oestrogen. Many of the thousands of chemicals released by humans into the environment, so-called xenobiotics, have the ability to disrupt normal endocrine function. Such endocrine-disrupting chemicals have been demonstrated to impair reproductive functions and to be responsible for numerous diseases in humans and wild life. Given that oestrogens are established modulators of immune cell populations, exogenous oestrogens and oestrogen mimics can modulate immune functions in aquatic animals, such as fish, potentially affecting wildlife and aquaculture. This review highlights the interaction of xenoestrogens with fish immunity. It particularly focusses on the thymus, a major primary immune organ, in the European seabass, Dicentrarchus labrax an important species, both for fisheries and aquaculture.