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DCTPP1: A promising target in cancer therapy and prognosis through nucleotide metabolism

Shaoxuan Liu1, Li Feng1, Zhe Wang1

  • 1State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Drug Discovery Today
|April 3, 2025
PubMed

Insights

Deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) is crucial for DNA stability by managing dNTP pools. Targeting DCTPP1 offers a promising strategy for novel cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) hydrolyzes deoxycytidine triphosphate (dCTP), maintaining deoxyribonucleoside triphosphate (dNTP) pool balance.
  • Proper dNTP pool homeostasis is essential for DNA replication fidelity and overall genome stability.
  • DCTPP1 plays a significant role in tumor progression, drug resistance, and predicting patient outcomes.

Purpose of the Study:

  • To review the structural and cellular characteristics of DCTPP1.
  • To summarize the known functions of DCTPP1 and its involvement in cancer.
  • To discuss emerging small molecules targeting DCTPP1 and suggest future research avenues.

Main Methods:

  • Literature review of structural and cellular biology studies on DCTPP1.
  • Analysis of research on DCTPP1's role in various cancers.
  • Survey of recent advancements in DCTPP1-targeting small molecules.

Main Results:

  • DCTPP1 is a key enzyme in nucleotide metabolism with implications in cancer.
  • Dysregulation of DCTPP1 is linked to tumor development and therapeutic resistance.
  • Small molecules targeting DCTPP1 are being developed as potential cancer therapeutics.

Conclusions:

  • DCTPP1 is a critical regulator of dNTP pools and a promising therapeutic target in oncology.
  • Further research into DCTPP1 inhibitors could lead to novel cancer treatment strategies.
  • Understanding DCTPP1's multifaceted roles is vital for advancing cancer therapy.
Keywords:
DCTPP1cancer therapydruggable targetnucleotide metabolismsmall-molecule inhibitors

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