Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

3.1K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.1K
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.1K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.1K
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

3.5K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
3.5K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

29
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
29

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospects of DNA nanotechnology in stroke repair and regeneration.

Communications biology·2026
Same author

Surface-Engineered Smart Carbon Quantum Dots at the Brain Interface for Neurotherapeutics and Brain Imaging: From Surface to Synapse.

Analytical chemistry·2026
Same author

Rationally designed mitochondria-impairing small molecule-enabled chemo-phototherapy to potentiate apoptosis and autophagy in cancer cells.

Journal of materials chemistry. B·2026
Same author

AI-Driven Design and Clinical Translation of Nucleotide-Peptide and Peptide-Drug Conjugates.

ACS biomaterials science & engineering·2026
Same author

Biomaterials and Nanoparticle-Based Therapeutics in Neurodegenerative Diseases: Bridging the Gap Between Innovation and Translation.

ACS chemical neuroscience·2026
Same author

A hybrid approach utilising adaptive laboratory evolution and gene expression analysis: How adaptive evolution improves PAHs biodegradation.

Journal of environmental management·2026
Same journal

Kinetic and Spatial Resolution by dSTORM of miniSOG-Mediated Proximity Labeling in Mammalian Cells.

Chembiochem : a European journal of chemical biology·2026
Same journal

Trylons: Polyamide Surrogate Substrates Enable High-Throughput Screening of Nylon-Degrading Enzymes.

Chembiochem : a European journal of chemical biology·2026
Same journal

Membrane-Associated Biomolecules for Synthetic Cell Signalling.

Chembiochem : a European journal of chemical biology·2026
Same journal

Hybrid Aminoferrocenes With Nitrate Esters for In Situ Peroxynitrite Generation: Complex Interplay Between Redox Chemistry, NO-Donor Reactivity, and Aminoferrocene Activation Influences In Vitro Anticancer Activity.

Chembiochem : a European journal of chemical biology·2026
Same journal

Towards the Enzymatic Labeling of Oligonucleotides With Triantennary N-Acetyl Galactosamine.

Chembiochem : a European journal of chemical biology·2026
Same journal

Structure and Activity of Class II Lanthipeptides From a Thermophilic Bacterium.

Chembiochem : a European journal of chemical biology·2026
See all related articles

Related Experiment Video

Updated: May 16, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

3.2K

Phase Separation in Biological Systems: Implications for Disease Pathogenesis.

Raj Dave1, Kshipra Pandey2, Ritu Patel2

  • 1Department of Chemistry, Indrashil University, Kadi, Mehsana, Gujarat, 382740, India.

Chembiochem : a European Journal of Chemical Biology
|April 3, 2025
PubMed
Summary
This summary is machine-generated.

Phase separation, crucial for cellular organization, is implicated in diseases like cancer and neurodegeneration. This review explores its role in disease and potential therapeutic targets.

Keywords:
cancerneurodegenerative disordersphase separation

More Related Videos

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

319
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

10.9K

Related Experiment Videos

Last Updated: May 16, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

3.2K
Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

319
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

10.9K

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Disease Pathogenesis

Background:

  • Phase separation drives the formation and function of biomolecular condensates in cells.
  • Aberrant phase separation is linked to various diseases, including neurodegenerative disorders, metabolic syndromes, and cancer.
  • Understanding the molecular basis of phase separation is key to understanding disease mechanisms.

Purpose of the Study:

  • To comprehensively review the role of phase separation in disease pathogenesis.
  • To analyze the involvement of single amino acids, carbohydrates, and nucleotides in disease-related phase separation.
  • To explore therapeutic strategies targeting phase separation for disease intervention.

Main Methods:

  • Literature review and comprehensive analysis of existing research.
  • Focus on molecular mechanisms of phase separation.
  • Examination of disease-specific examples and therapeutic interventions.

Main Results:

  • Phase separation is a critical cellular process with significant implications in disease.
  • Specific molecular components like amino acids, carbohydrates, and nucleotides influence phase separation in disease.
  • Dysregulated phase separation contributes to the pathogenesis of major diseases.

Conclusions:

  • Phase separation is a key player in cellular organization and disease development.
  • Targeting phase separation offers promising therapeutic avenues for various diseases.
  • Further research into the molecular mechanisms can unlock new treatment strategies.