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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

782
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

715
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

716
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
716

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Local and systemic immune correlates of anal high-risk HPV infection and clearance in men living with HIV and men at high risk for HIV.

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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[Lymphadenopathy - infection or malignancy?]

Sabine Ehrlich1, Karsten Spiekermann2, Johannes R Bogner3

  • 1Medizinische Klinik und Poliklinik III, Klinikum der LMU München, Marchioninistraße 15, 81377, München, Deutschland. sabine.ehrlich@med.uni-muenchen.de.

MMW Fortschritte Der Medizin
|April 3, 2025
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Summary
This summary is machine-generated.

Persistent lymphadenopathy, or enlarged lymph nodes, presents a diagnostic challenge. This guide outlines key diagnostic steps and common differential diagnoses for adult patients to ensure timely therapy.

Keywords:
HIVLymphadenopathybiopsylymphoma

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Area of Science:

  • Internal Medicine
  • Pathology
  • Oncology

Context:

  • Persistent lymphadenopathy is a common clinical finding.
  • Enlarged lymph nodes can indicate a wide range of underlying conditions.
  • Distinguishing between benign and malignant causes is critical for patient management.

Purpose:

  • To provide physicians with an overview of diagnostic strategies for persistent lymphadenopathy.
  • To highlight common differential diagnoses in adult patients.
  • To emphasize the importance of early detection of malignant diseases.

Summary:

  • This article reviews essential diagnostic steps for evaluating persistent lymphadenopathy in adults.
  • It covers common causes, including infections, non-malignant conditions, and malignancies.
  • The focus is on facilitating accurate diagnosis and appropriate management.

Impact:

  • Improved diagnostic accuracy for persistent lymphadenopathy.
  • Reduced delays in identifying and treating malignant conditions.
  • Enhanced clinical decision-making for physicians managing enlarged lymph nodes.