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Obesity and sleep disorders: A bidirectional relationship
Michela Figorilli1, Fernanda Velluzzi2, Stefania Redolfi1
1Sleep Disorder Research Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Summary
Obesity and sleep disorders worsen each other through complex mechanisms. Addressing both conditions together is crucial for improving cardiometabolic health and overall well-being.
Area of Science:
- Endocrinology
- Sleep Medicine
- Public Health
Background:
- Obesity and sleep disorders are prevalent, impacting public health.
- A bidirectional relationship exists where each condition exacerbates the other.
- Mechanisms involve hormonal, behavioral, and physiological factors.
Purpose of the Study:
- To review the pathophysiological mechanisms linking obesity and sleep disorders.
- To explore the role of inflammation, autonomic dysregulation, and neuroendocrine pathways.
- To examine specific sleep disorders like OSAS and RLS in the context of obesity.
Main Methods:
- Literature review of existing research.
- Analysis of pathophysiological pathways.
- Examination of specific sleep disorders and their link to obesity.
Main Results:
- Sleep deprivation impacts energy balance via appetite hormones and reduced activity.
- Obesity increases the prevalence of sleep disorders like OSAS, insomnia, and RLS.
- Shared pathways include inflammation, autonomic dysregulation, and neuroendocrine disruption.
Conclusions:
- Integrated management of sleep and obesity is vital for better health outcomes.
- Addressing this bidirectional link can mitigate cardiometabolic comorbidities.
- Holistic treatment approaches are needed for physical, psychological, and sleep dimensions.
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