Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

1.6K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
1.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: <sup>1</sup>H-NMR serum metabolomic profiling from clinical routine identifies signatures of progressive melanoma metastasis.

Scientific reports·2026
Same author

Eosinophilic fasciitis induced by checkpoint inhibitors: a retrospective multicenter case-series, comparison with eosinophilic fasciitis unrelated to checkpoint inhibition and literature review.

Journal of the American Academy of Dermatology·2026
Same author

Extracting Medical Information From Unstructured Clinical Text Using Large Language Models to Enhance Health Care Interoperability: Proof-of-Concept Study.

Journal of medical Internet research·2026
Same author

Years of life lost in patients with a false-negative diagnosis of primary melanoma. A prospective study of the German Central Malignant Melanoma Registry involving 9063 patients over 28 years.

Nature communications·2026
Same author

Recent Advances in Automated Mitosis Detection in Digital Pathology: A PRISMA-Guided Systematic Review with Evaluation-Regime Stratification (2018-2025).

Biomedicines·2026
Same author

Personalized targeting of BCL2 family proteins overcomes acquired resistance to BRAF-MEK inhibitors in preclinical melanoma.

Nature communications·2026

Related Experiment Video

Updated: May 17, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.6K

Cutaneous melanoma.

Alpaslan Tasdogan1,2, Ryan J Sullivan3, Alexander Katalinic4

  • 1Department of Dermatology, University Hospital Essen & German Cancer Consortium (DKTK), Partner Site Essen, Essen, Germany. alpaslan.tasdogan@uk-essen.de.

Nature Reviews. Disease Primers
|April 3, 2025
PubMed
Summary
This summary is machine-generated.

Cutaneous melanoma, a growing cancer risk globally, is strongly linked to UV radiation and genetic mutations. Advances in immunotherapy and targeted therapies are improving patient outcomes and guiding future research.

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.1K

Related Experiment Videos

Last Updated: May 17, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.6K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.1K

Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Cutaneous melanoma incidence is rising globally, particularly in Australia, New Zealand, Europe, and North America.
  • Ultraviolet (UV) radiation is the primary risk factor, though public awareness has reduced mortality.
  • Genetic alterations and the tumor microenvironment significantly influence melanoma development and progression.

Purpose of the Study:

  • To review the current understanding of cutaneous melanoma, including risk factors, pathogenesis, and treatment advancements.
  • To highlight key areas for future research and management strategies in melanoma.

Main Methods:

  • Review of existing literature on cutaneous melanoma epidemiology, risk factors, and molecular mechanisms.
  • Analysis of recent therapeutic developments, including immunotherapy and targeted therapies.
  • Discussion of future research priorities in precision medicine and clinical management.

Main Results:

  • UV radiation and specific genetic mutations are critical in melanoma development.
  • Tumor stage at diagnosis is a key prognostic factor.
  • Significant treatment improvements have been achieved with immune checkpoint inhibitors and BRAF/MEK targeted therapies.

Conclusions:

  • Continued advances in precision medicine are essential for tailoring treatments to individual patients.
  • Future research should focus on improving early detection and optimizing combination therapies.
  • Understanding the interplay between genetics, UV exposure, and the tumor microenvironment is crucial for combating melanoma.