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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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Human lifespan changes in the brain's functional connectome.

Lianglong Sun1,2,3, Tengda Zhao1,2,3, Xinyuan Liang1,2,3

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Human brain functional connectivity evolves across the lifespan. This study reveals key changes in brain networks from infancy to old age, offering a normative reference for development and disorders.

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Area of Science:

  • Neuroscience
  • Human Brain Development
  • Connectomics

Background:

  • Human brain functional connectivity undergoes significant changes throughout life.
  • Understanding these changes is crucial for identifying developmental trajectories and aging processes.

Purpose of the Study:

  • To map the lifespan evolution of the human brain's functional connectome.
  • To establish normative growth curves for brain connectivity from infancy to old age.
  • To identify distinct maturation timelines for different brain systems.

Main Methods:

  • Assembled task-free functional and structural MRI data from 33,250 individuals (32 weeks postmenstrual age to 80 years) across 132 global sites.
  • Analyzed nonlinear growth curves for global mean and variance of the connectome.
  • Developed system-level brain atlases to examine functional segregation and regional connectivity patterns.

Main Results:

  • Identified critical inflection points in connectome growth curves, peaking in the late third and fourth decades of life.
  • Revealed distinct maturation timelines for functional segregation across different brain systems.
  • Demonstrated that lifespan growth of regional connectivity follows a spatiotemporal cortical axis, moving from sensorimotor to association regions.

Conclusions:

  • The study provides a comprehensive map of functional connectome evolution across the human lifespan.
  • These findings offer a normative reference for quantifying individual variations in brain development, aging, and neuropsychiatric disorders.
  • Elucidates the dynamic changes in brain network organization from early development through senescence.