Angiotensin II enhances calcium exchanges in isolated rat aorta

The effect of angiotensin II (AII) on calcium exchanges in isolated rat aorta was investigated using the 45Ca lanthanum technique. AII induced a rapid (10 s) and long-lasting (120 min) increase of calcium uptake and enhanced calcium release for a short period. AII-stimulated calcium uptake was antagonized by saralasin and verapamil but not by indomethacin. These data indicate that AII increases rat aortic calcium exchanges via receptor-operated and voltage-dependent calcium channels.