Related Experiment Video
Updated: May 16, 2025

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
Facial Skin Aging: Effect of Aging in Different Layers of the Skin on Wrinkles and Sagging
Dangdang Cheng1,2, Qin Zhang1,2, Wanwen Shan1,2
1Shanghai Jiyan Bio-Pharmaceutical Co. Ltd., Shanghai, China.
Objective:
To investigate the impact of aging in different skin layers on the formation of wrinkles and sagging.
Methods:
In a single-center clinical study, the skin micromorphology, wrinkles, and sagging of 34 participants aged 42-60 years who use an antiaging product for 56 days are discussed retrospectively and observationally. The variation trend of each parameter and the correlation between micromorphology parameters and wrinkles and sagging are analyzed.
Results:
Parameters related to epidermal aging show a strong correlation with wrinkles and sagging, whereas parameters related to dermal aging show no significant correlation with wrinkles and sagging; in addition, parameters related to the dermal-epidermal junction (DEJ) show a moderate correlation with wrinkles and sagging.
Conclusion:
For individuals in the rapid and stable aging phases, aging of the epidermis has a greater impact on wrinkles and sagging than aging of the dermis and DEJ.
More Related Videos
Related Concept Videos
The Effect of Aging on Tissues
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Layers of the Epidermis
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
Cells of the Epidermis
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Muscles for Facial Expressions

