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Trabecular Bone Score in Asian-Indian Post-menopausal Women Across the Spectrum of Hyperglycaemia: Insights from a Cross-Sectional Study

  • 0Department of Cardiology, PGIMER, Chandigarh, India.
Indian Journal of Endocrinology and Metabolism +

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April 4, 2025

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April 4, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Type 2 diabetes mellitus (T2DM) is linked to higher fracture risk, even with normal bone density. Trabecular bone score (TBS) is lower in T2DM patients, indicating its value in assessing bone health.

Area Of Science

  • Endocrinology
  • Osteoporosis Research
  • Bone Metabolism

Background

  • Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fragility fractures.
  • Areal bone mineral density (aBMD) may not accurately reflect fracture risk in T2DM patients.
  • Trabecular bone score (TBS) is being investigated as a complementary metric for bone health assessment in T2DM.

Purpose Of The Study

  • To determine and compare Trabecular Bone Score (TBS) in post-menopausal women with T2DM versus non-diabetic individuals.
  • To evaluate the utility of TBS as an alternative bone health metric in T2DM.
  • To investigate the correlation between glycaemic control and TBS in T2DM.

Main Methods

  • Cross-sectional study involving 101 T2DM patients and 101 controls (pre-diabetes and normoglycaemic).
  • Participants underwent clinical assessment, biochemical tests, and dual-energy X-ray absorptiometry (DXA) with TBS measurement.
  • Comparison of aBMD and TBS values across T2DM, pre-diabetes, and normoglycaemic groups.

Main Results

  • No significant difference in aBMD was observed among the three groups.
  • Mean TBS was significantly lower in the T2DM group compared to pre-diabetes and normoglycaemic groups (P < 0.001).
  • Higher HbA1c and longer diabetes duration correlated negatively with TBS.

Conclusions

  • TBS is a valuable tool for assessing bone health in T2DM patients, especially when aBMD is insufficient for fracture risk prediction.
  • Glycaemic control and diabetes duration significantly influence TBS.
  • Integrating TBS with aBMD provides a more comprehensive bone health evaluation in T2DM.

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