Association between systemic inflammation indicators and psoriasis: a cross-sectional study from NHANES

Area of Science:

• Dermatology
• Immunology
• Public Health

Background:

• Psoriasis is a chronic inflammatory skin condition with potential systemic implications.
• Systemic inflammation is increasingly recognized as a contributing factor in various chronic diseases, including psoriasis.

Purpose of the Study:

• To investigate the association between systemic inflammatory indicators and psoriasis in the adult population of the United States.
• To evaluate the predictive efficacy of these indicators in relation to psoriasis prevalence.

Main Methods:

• Analysis of data from 16,575 adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2003-2014.
• Utilized multivariable logistic regression and nonlinear curve fitting to assess associations between psoriasis and inflammatory markers (NPAR, NLR, NHR, LHR, PHR, MHR).
• Performed subgroup analyses and ROC curve analysis to assess predictive accuracy.

Main Results:

• A significant positive association was observed between psoriasis and NPAR and NLR.
• Each 10-unit increase in NPAR correlated with a 90% higher odds of psoriasis; each unit increase in NLR correlated with a 10% higher odds.
• Nonlinear relationships were identified between psoriasis and NPAR, NLR, and NHR, with specific breakpoints.
• NLR and NPAR demonstrated better accuracy in predicting psoriasis prevalence via ROC analysis.

Conclusions:

• The study indicates a positive affiliation between NPAR, NLR, and the occurrence of psoriasis.
• These findings suggest potential utility of NPAR and NLR as indicators for psoriasis risk.
• Further prospective research is warranted to confirm these associations and elucidate underlying mechanisms.