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Association between oxidative balance score and all-cause and cancer-specific mortality among cancer survivors.

Qingmei Gao1, Xinfang Zhu1, Mengke Chen1

  • 1Department of Blood Transfusion, Huashan Hospital, Fudan University, Shanghai, China.

Frontiers in Immunology
|April 4, 2025
PubMed
Summary
This summary is machine-generated.

Higher Oxidative Balance Scores (OBS) are linked to reduced mortality in cancer survivors. This suggests OBS may help refine lifestyle interventions for improved outcomes.

Keywords:
all-cause mortalitycancer mortalitycancer survivorsdietlifestyleoxidative balance score

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Area of Science:

  • Biostatistics
  • Epidemiology
  • Nutritional Science

Background:

  • The Oxidative Balance Score (OBS) is a novel metric assessing systemic oxidative stress.
  • Elevated OBS indicates increased antioxidant exposure.
  • This study investigates the association between OBS and mortality in cancer survivors.

Purpose of the Study:

  • To explore the relationship between the Oxidative Balance Score (OBS) and all-cause mortality.
  • To examine the association between OBS and cancer-specific mortality.
  • To assess the impact of OBS on mortality risks in cancer survivors.

Main Methods:

  • An observational cohort study of 4099 cancer survivors using NHANES data (1999-2018).
  • Endpoints determined via National Death Index (NDI) linkage.
  • Cox proportional hazards regression and restricted cubic splines analyzed OBS-mortality association.

Main Results:

  • A higher OBS was associated with decreased all-cause and cancer-specific mortality.
  • Each unit increase in OBS correlated with a 1.8% reduction in all-cause mortality risk.
  • Significant reductions in mortality were observed across higher OBS quartiles (Q2-Q4) compared to Q1.

Conclusions:

  • Increased OBS is significantly associated with lower all-cause and cancer-specific mortality in cancer survivors.
  • Findings support OBS as a valuable tool for assessing health status in cancer survivors.
  • The study may inform lifestyle intervention strategies for improving survival in this population.