A machine learning model based on emergency clinical data predicting 3-day in-hospital mortality for stroke and...

Accurately predicting the short-term in-hospital mortality risk for patients with stroke and TBI (Traumatic Brain Injury) is crucial for improving the quality of emergency medical care.

This study analyzed data from 2,125 emergency admission patients with stroke and traumatic brain injury at two Grade a hospitals in China from January 2021 to March 2024. LASSO regression was used for feature selection, and the predictive performance of logistic regression was compared with six machine learning algorithms. A 70:30 ratio was applied for cross-validation, and confidence intervals were calculated using the bootstrap method. Temporal validation was performed on the best-performing model. SHAP values were employed to assess variable importance.

The random forest algorithm excelled in predicting in-hospital 3-day mortality, achieving an AUC of 0.978 (95% CI: 0.966-0.986). Time series validation demonstrated the model's strong generalization capability, with an AUC of 0.975 (95% CI: 0.963-0.986). Key predictive factors in the final model included metabolic syndrome, NEWS2 score, Glasgow Coma Scale (GCS), whether surgery was performed, bowel movement status, potassium level (K), aspartate transaminase (AST) level, and temporal factors. SHAP value analysis further confirmed the significant contributions of these variables to the predictive outcomes. The random forest model developed in this study demonstrates good accuracy in predicting short-term in-hospital mortality rates for stroke and traumatic brain injury patients. The model integrates emergency scores, clinical signs, and key biochemical indicators, providing a comprehensive perspective for risk assessment. This approach, which incorporates emergency data, holds promise for assisting decision-making in clinical practice, thereby improving patient outcomes.