Related Experiment Video

Updated: May 16, 2025

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
08:05

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

2.6K

Takeda G protein-coupled receptor 5 (TGR5): an attractive therapeutic target for aging-related cardiovascular

Yufeng He1, Siqi Liu1, Yali Zhang1

  • 1Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Frontiers in Pharmacology
|April 4, 2025
PubMed

Insights

Aging accelerates cardiovascular diseases (CVDs). Takeda G protein-coupled receptor 5 (TGR5), a bile acid receptor, is implicated in aging-related CVDs, offering a potential therapeutic target.

Area of Science:

  • Gerontology
  • Cardiology
  • Molecular Biology

Background:

  • Aging is a primary risk factor for numerous chronic conditions, including cardiovascular diseases (CVDs).
  • Mechanisms underlying aging-related CVDs are under intense investigation.
  • Takeda G protein-coupled receptor 5 (TGR5) is a bile acid receptor involved in inflammation, oxidative stress, and metabolic disorders, all relevant to aging and CVDs.

Purpose of the Study:

  • To review the role of TGR5 in the context of aging-related cardiovascular diseases.
  • To explore TGR5's mechanisms of involvement in these conditions.
  • To evaluate TGR5 as a potential therapeutic target for aging-related CVDs.

Main Methods:

  • This study is a review of existing literature.
  • It synthesizes current research on TGR5 function in aging and cardiovascular health.
  • It analyzes the mechanistic links between TGR5, aging processes, and CVD development.

Main Results:

  • TGR5 plays a significant role in processes contributing to aging-related CVDs, including inflammation, oxidative stress, and metabolic dysregulation.
  • The receptor's involvement is multifaceted, impacting various cellular and systemic pathways relevant to cardiovascular aging.
  • Evidence suggests TGR5 modulation could counteract detrimental aging effects on the cardiovascular system.

Conclusions:

  • TGR5 is a key player in the pathogenesis of aging-related cardiovascular diseases.
  • Understanding TGR5's mechanisms provides insights into cardiovascular aging.
  • TGR5 presents a promising and attractive therapeutic target for the development of novel drugs to combat aging-related CVDs.
Keywords:
TGR5agingcardiovascular diseaseheart failuremyocardial infarction

More Related Videos

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.7K
A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

8.6K

Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
10.9K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.3K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
1.8K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
4.5K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
113.3K