Related Experiment Video
Updated: May 16, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
[Retracted] Everolimus inhibits breast cancer cell growth through PI3K/AKT/mTOR signaling pathway
Liyan Du1, Xiaomei Li1, Linhong Zhen1
1Department of Breast Surgery, Xingtai First Hospital, Xingtai, Hebei 054001, P.R. China.
Abstract:
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the Transwell migration and invasion assay data shown in Fig. 3E and F on p. 7166 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had already been published elsewhere prior to the submission of this paper to Molecular Medicine Reports. In view of the fact that the abovementioned data had already apparently been published previously, the Editor of Molecular Medicine Reports has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 17: 7163‑7169, 2018; DOI: 10.3892/mmr.2018.8769].
Insights
This study was retracted due to duplicate data in Transwell migration and invasion assays. The editors found similarities to previously published work, and the authors did not respond to inquiries. This highlights the importance of data integrity in scientific publishing.
Area of Science:
- Cell Biology
- Scientific Publishing Ethics
Background:
- Concerns were raised regarding data duplication in published research.
- Specifically, Transwell migration and invasion assay data were found to be highly similar to previously published findings from other institutions.
Purpose of the Study:
- To address concerns of data duplication and plagiarism.
- To maintain the integrity of scientific records.
Main Methods:
- Review of submitted manuscript data.
- Comparison with previously published data from external sources.
Main Results:
- Identified significant similarities between the current study's Transwell assay data and pre-existing published data.
- Authors failed to provide a satisfactory explanation or rebuttal.
Conclusions:
- The paper has been retracted due to concerns of duplicate publication.
- This retraction underscores the critical importance of original data submission and ethical research practices.
More Related Videos
06:00Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
Published on: September 13, 2017
08:48An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
Published on: June 30, 2015
Related Concept Videos
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway
Inhibition of Cdk Activity
Mitogens and the Cell Cycle
Targeted Cancer Therapies
There are several types of targeted therapies against...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...