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[Retracted] miR‑217 inhibits the migration and invasion of HeLa cells through modulating MAPK1
Lihong Zhu1, Shumei Yang2, Jianfeng Wang3
1The Second Clinical Medical College, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China.
Abstract:
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, regarding the Transwell invasion assay experiments shown in Figs. 2D and 5F, the 'Mimic control' panel in Fig. 2D appeared to contain an overlapping section of data with the 'Blank' data panel in Fig. 5F, such that data which were intended to show the results from differently performed experiments had apparently been derived from the same original source. In addition, the control western blot data (GAPDH protein bands) shown in the western blots in Figs. 3C and 5H were apparently the same, although the images had been inserted into these figures as mirror images of each other. In view of the fact that these figures were assembled erroneously, the Editor of International Journal of Molecular Medicine has decided that this paper should be retracted from the Journal on account of a lack of confidence in the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Molecular Medicine 44: 1824‑1832, 2019; DOI: 10.3892/ijmm.2019.4328].
Insights
This study is retracted due to concerns about data integrity. Duplicate and mirrored images in Transwell invasion assays and western blots raise significant doubts about the presented scientific findings.
Area of Science:
- Molecular Medicine
- Cell Biology
Background:
- Concerns were raised regarding data duplication and manipulation in published research.
- Specific figures in the study showed overlapping data and mirrored images.
Purpose of the Study:
- To address concerns about data integrity and experimental reproducibility.
- To investigate potential data fabrication or misrepresentation in scientific figures.
Main Methods:
- Review of experimental data presented in figures.
- Comparison of images from Transwell invasion assays and western blots.
- Editor's inquiry to authors regarding data discrepancies.
Main Results:
- Identified overlapping data between 'Mimic control' in Fig. 2D and 'Blank' in Fig. 5F.
- Observed identical GAPDH protein bands in western blots (Figs. 3C and 5H) presented as mirror images.
- Authors failed to provide a satisfactory explanation for the data discrepancies.
Conclusions:
- The study is retracted due to a lack of confidence in the presented data.
- Erroneous assembly of figures and data manipulation undermine the study's validity.
- Retraction serves to maintain scientific integrity and protect the readership.
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