[Retracted] miR‑217 inhibits the migration and invasion of HeLa cells through modulating MAPK1

Lihong Zhu1, Shumei Yang2, Jianfeng Wang3

  • 1The Second Clinical Medical College, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China.

Insights

This study is retracted due to concerns about data integrity. Duplicate and mirrored images in Transwell invasion assays and western blots raise significant doubts about the presented scientific findings.

Area of Science:

  • Molecular Medicine
  • Cell Biology

Background:

  • Concerns were raised regarding data duplication and manipulation in published research.
  • Specific figures in the study showed overlapping data and mirrored images.

Purpose of the Study:

  • To address concerns about data integrity and experimental reproducibility.
  • To investigate potential data fabrication or misrepresentation in scientific figures.

Main Methods:

  • Review of experimental data presented in figures.
  • Comparison of images from Transwell invasion assays and western blots.
  • Editor's inquiry to authors regarding data discrepancies.

Main Results:

  • Identified overlapping data between 'Mimic control' in Fig. 2D and 'Blank' in Fig. 5F.
  • Observed identical GAPDH protein bands in western blots (Figs. 3C and 5H) presented as mirror images.
  • Authors failed to provide a satisfactory explanation for the data discrepancies.

Conclusions:

  • The study is retracted due to a lack of confidence in the presented data.
  • Erroneous assembly of figures and data manipulation undermine the study's validity.
  • Retraction serves to maintain scientific integrity and protect the readership.

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