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Updated: Jun 29, 2026
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Constructing a prognostic model based on MPT-related genes and investigate the characteristics of immune infiltration
Lei Yang1,2, Zhiqiang Zhang3,4, Mengfan Xu1,2
1Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui Province, China.
Purpose:
Exploring the expression of Mitochondrial Permeability Transition Dependent Necrosis lncRNA in bladder cancer and elucidate their precise function within the tumor microenvironment and impact on prognosis.
Methods:
We employed a comprehensive bioinformatics approach to investigate the function and influence of lncRNA in bladder cancer. Gene expression data, clinical data, and mutation data of bladder cancer are obtained from TCGA database.
Results:
We developed a new prognostic model incorporating 6 lncRNAs. The predictive efficacy of this model for bladder cancer prognosis was validated. Furthermore, we investigated the influence of model on the tumor microenvironment and drug sensitivity.
Conclusion:
This study presents a novel prognostic framework for bladder cancer that holds great potential for enhancing prognostic prediction accuracy and optimizing treatment strategies for patients with this disease.
