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    Area of Science:

    • Medical Imaging
    • Biomedical Engineering
    • Ultrasound Technology

    Background:

    • Ultrafast ultrasound imaging is vital for clinical diagnostics.
    • Null subtraction imaging (NSI) enhances lateral resolution but has poor contrast and speckle quality.
    • Existing methods struggle to balance resolution and contrast.

    Purpose of the Study:

    • To develop a novel contrast-enhanced NSI method for ultrafast ultrasound imaging.
    • To address the limitations of traditional NSI, specifically poor contrast and speckle patterns.
    • To improve the accuracy and diagnostic value of clinical ultrasound.

    Main Methods:

    • Proposed a novel contrast-enhanced NSI using dynamic dc bias.
    • Constructed dynamic dc bias with a generalized coherence factor (GCF) and sigmoid transformation.
    • Implemented a normalization scheme for uniform pixel intensity.
    • Evaluated performance using simulation, phantom, and in vivo ultrasound data.

    Main Results:

    • Achieved significant enhancements in contrast ratio (197%), contrast-to-noise ratio (341%), speckle SNR (302%), and generalized CNR (106%) compared to original NSI (in phantom).
    • Main lobe width was slightly wider than original NSI but narrower than DAS and GCF.
    • Demonstrated superior contrast enhancement while maintaining high resolution.

    Conclusions:

    • The proposed method substantially improves image contrast in ultrafast ultrasound.
    • It effectively preserves high resolution, overcoming NSI's limitations.
    • This advancement holds significant potential for clinical applications of ultrafast ultrasound imaging.