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Characteristics and Associated Survival of Patients Diagnosed With Non-Small Cell Lung Cancer in a Designated Lung

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This summary is machine-generated.

Lung cancer patients in western Kenya present with advanced disease and poor survival, highlighting a need for early diagnosis interventions. Despite case-finding efforts, late diagnosis is common, necessitating locally relevant solutions for improved lung cancer outcomes.

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Area of Science:

  • Oncology
  • Public Health
  • Epidemiology

Background:

  • Lung cancer is a leading global cause of cancer mortality.
  • Studies on lung cancer in sub-Saharan Africa are limited.
  • A lung cancer program was established in western Kenya for case finding, diagnosis, and treatment.

Purpose of the Study:

  • To present findings from a lung cancer program in western Kenya.
  • To analyze the characteristics, treatment, and survival of non-small cell lung cancer (NSCLC) patients.
  • To identify challenges and needs for improving lung cancer care in the region.

Main Methods:

  • Retrospective review of pathologically confirmed NSCLC patients from January 2018 to December 2022.
  • Analysis of clinical data using descriptive statistics.
  • Kaplan-Meier methods and proportional hazards regression for survival analysis.

Main Results:

  • 249 NSCLC patients were included, with a median age of 61.
  • Most patients were married (71%) and non-smokers (71%).
  • Predominant histology was adenocarcinoma (75%), with advanced stage IV (78%) or unstaged disease (16%) at diagnosis.
  • Median overall survival was 3.7 months.
  • Poor Eastern Cooperative Oncology Group (ECOG) performance status (PS) and unstaged disease predicted poor 1-year survival.

Conclusions:

  • NSCLC patients in this program presented with advanced disease and poor survival.
  • Late diagnosis remains a significant challenge despite case-finding efforts.
  • There is a critical need for locally relevant interventions, including community/provider education, innovative diagnostics, and access to treatments like molecular therapies and palliative care to improve lung cancer survival.