Chiroptical hybrid nanomaterials based on metal nanoparticles and biomolecules

Chirality at the nanoscale has recently attracted renewed attention from the scientific community. As a result, various strategies have been proposed to develop chiral nanomaterials based on metal nanoparticles and chiral biomolecules such as DNA, amino acids, or proteins. We review herein the past and recent literature related to the functionalization of metal nanoparticles with various chiral biomolecules and their assembly into biomaterials with chiroptical response. We divide the review into two main parts, according to the class of biomolecules. We first discuss mechanisms employed to obtain chiral bioconjugates based on metal nanoparticles and amino acids or their derivatives (peptides and proteins), including mechanisms for chirality transfer from chiral biomolecules to achiral nanoparticles. We also review the use of amino acids/peptides as either chiral inducers for the growth of chiral nanoparticles or templates for the chiral arrangement of achiral nanoparticles. In the second part we present an overview of methods to prepare bioconjugates comprising DNA and metal nanoparticles, as well as selected examples of helical nanoparticle arrangements that employ DNA as a chiral template.