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MicroRNAs in patients with pemphigus: A systematic review

Zahra Razavi1, Nafiseh Esmaeili1, Saba Katebian1

  • 1Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

International Immunopharmacology
|April 4, 2025
PubMed
Abstract

Insights

MicroRNAs show promise in diagnosing and predicting pemphigus, a severe autoimmune blistering disease. Further research is needed to confirm their clinical application in dermatology.

Area of Science:

  • Dermatology
  • Autoimmune Diseases
  • Molecular Biology

Background:

  • Pemphigus is a group of severe autoimmune blistering diseases (AIBDs).
  • The role of microRNAs (miRNAs) in pemphigus pathogenesis is an emerging area of dermatological research.

Purpose of the Study:

  • To systematically review the role of microRNAs in the diagnosis and severity evaluation of pemphigus disease.

Main Methods:

  • A systematic literature search was conducted on PubMed, Scopus, Embase, and Web of Science.
  • Studies published from 1990 to February 2025 were included.

Main Results:

  • Eight studies were identified in the systematic review.
  • The expression levels of 18 types of microRNAs were found to be significantly different in pemphigus patients compared to healthy individuals.

Conclusions:

  • MicroRNAs may serve as potential biomarkers for pemphigus diagnosis and disease course prediction.
  • Clinical validation of these microRNA findings is required.
Keywords:
Autoimmune bullous diseasesPemphigusPemphigus foliaceusPemphigus vulgarismicroRNA

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