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MicroRNAs in patients with pemphigus: A systematic review
Zahra Razavi1, Nafiseh Esmaeili1, Saba Katebian1
1Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
International Immunopharmacology
|April 4, 2025
Summary
MicroRNAs show promise in diagnosing and predicting pemphigus, a severe autoimmune blistering disease. Further research is needed to confirm their clinical application in dermatology.
Area of Science:
- Dermatology
- Autoimmune Diseases
- Molecular Biology
Background:
- Pemphigus is a group of severe autoimmune blistering diseases (AIBDs).
- The role of microRNAs (miRNAs) in pemphigus pathogenesis is an emerging area of dermatological research.
Purpose of the Study:
- To systematically review the role of microRNAs in the diagnosis and severity evaluation of pemphigus disease.
Main Methods:
- A systematic literature search was conducted on PubMed, Scopus, Embase, and Web of Science.
- Studies published from 1990 to February 2025 were included.
Main Results:
- Eight studies were identified in the systematic review.
- The expression levels of 18 types of microRNAs were found to be significantly different in pemphigus patients compared to healthy individuals.
Conclusions:
- MicroRNAs may serve as potential biomarkers for pemphigus diagnosis and disease course prediction.
- Clinical validation of these microRNA findings is required.
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