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Updated: May 16, 2025
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
Published on: July 5, 2024
Exploring the genetic association between inflammatory cytokines and primary ovarian insufficiency: A Mendelian
Jie Wu1, Yancheng Fu2, Zhengqi Qiu3
1Department of Pharmacy, People's Hospital of Longhua, Shenzhen City, Guangdong Province 518109, China.
Purpose:
This study aims to investigate the genetic underpinnings of Primary Ovarian Insufficiency (POI) by examining the association between 91 inflammatory cytokines identified through genome-wide association studies (GWAS) and POI, using Mendelian randomization (MR) to explore potential causal relationships.
Methods:
We utilized Mendelian Randomization (MR) to investigate the causative links between inflammatory cytokines and POI, selecting genetic variants associated with cytokine levels as instrumental variables.
Results:
Utilizing the Inverse Variance Weighted (IVW) method, our Mendelian Randomization (MR) study elucidated the influence of inflammatory cytokines on POI. We discovered that certain cytokines exhibit a protective association: CC motif chemokine 19 (CCL19) [OR 0.58; 95 % CI: 0.36-0.93; p = 0.024], Interleukin-10 (IL-10) [OR 0.41; 95 % CI: 0.23-0.72; p = 0.002], Interleukin-17 A (IL-17 A) [OR 0.44; 95 % CI: 0.20-0.96; p = 0.040], and Monocyte chemotactic protein 3 (MCP-3) [OR 0.51; 95 % CI: 0.29-0.89; p = 0.018]. Conversely, an elevated level of interleukin-33 in blood plasma was identified as a risk factor for POI [OR 2.83; 95 % CI: 1.23-6.50; p = 0.015].
Conclusion:
Our findings indicate a significant correlation between specific inflammatory cytokines and the risk of developing POI. The negative association of cytokines such as CCL19, IL-10, IL-17 A, and MCP-3 suggests a protective effect against POI, whereas the positive association of IL-33 levels implies a potential adverse impact. These insights could guide future research towards targeted immunomodulatory therapies for the management and prevention of POI.
