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Updated: Jun 14, 2025

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
How green are radiopharmaceutical sciences?
Verena Pichler1, Matthias Manfred Herth2, Verena Hugenberg3
1Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria; Department of Pharmacy, University of Oslo, Sem Sælands vei 3, 0371 Oslo, Norway.
Radiopharmaceutical sciences need sustainable practices. This study proposes nine tailored green chemistry and engineering principles to reduce waste and energy use in nuclear medicine development.
Area of Science:
- Radiopharmaceutical Sciences
- Nuclear Medicine
- Green Chemistry
Background:
- The radiopharmaceutical sector is rapidly expanding, driven by theranostic agents and PET imaging.
- Increasing demand presents challenges in energy consumption and waste management for nuclear medicine.
- The nuclear medicine market is projected to reach $30 billion by 2030.
Purpose of the Study:
- To examine the applicability of green chemistry and engineering principles in radiopharmaceutical sciences.
- To propose tailored sustainability principles for the field.
- To address environmental impact reduction in radiopharmaceutical development.
Main Methods:
- Review of the 12 principles of green chemistry and engineering.
- Adaptation of traditional sustainability frameworks for radiopharmaceutical specific needs.
- Development of nine key principles for sustainable radiopharmaceutical sciences.
Main Results:
- Identification of specific challenges in applying sustainability to radiopharmaceuticals, including radiation safety, speed, and automation.
- Proposal of nine tailored principles focusing on waste prevention, radionuclide recycling, energy efficiency, and cleaner irradiation technologies.
- Emphasis on the need for integrating sustainability into training and research.
Conclusions:
- Sustainability principles are crucial for the growing field of radiopharmaceutical sciences.
- Nine adapted principles offer a framework for greener radiopharmaceutical development.
- Future integration of sustainability into education and research is essential for long-term environmental responsibility.
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