Related Experiment Video
Updated: May 17, 2025

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
Tonsils weigh in on flu-specific immunity
1Department of Women's and Children's Health, Karolinska Institutet, 17165 Solna, Sweden; Department of Immunology and Inflammation, Imperial College London, London, UK; Medical Research Council London Institute of Medical Sciences (LMS), Imperial College Hammersmith Campus, London, UK.
Abstract:
Wagoner et al.1 use human tonsil organoids to uncover key immune mechanisms driving influenza vaccine responses. They identify Th1 cell frequencies as a critical predictor of neutralizing antibody responses to inactivated vaccines, providing new insights into vaccine effectiveness and paving the way for more targeted vaccine development in the future.
More Related Videos
Related Concept Videos
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Tonsillitis II: Management
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Vaccinations

