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Updated: May 20, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Advances in the study of epithelial mesenchymal transition in cancer progression: Role of miRNAs
Jia Zhang1, Runting Yin1, Yongwang Xue1
1School of Pharmacy, Jiangsu University, Zhen Jiang, 212013, China.
Abstract:
Epithelial-mesenchymal transition (EMT) has been extensively studied for its roles in tumor metastasis, the generation and maintenance of cancer stem cells and treatment resistance. Epithelial mesenchymal plasticity allows cells to switch between various states within the epithelial-mesenchymal spectrum, resulting in a mixed epithelial/mesenchymal phenotypic profile. This plasticity underlies the acquisition of multiple malignant features during cancer progression and poses challenges for EMT in tumors. MicroRNAs (miRNAs) in the microenvironment affect numerous signaling processes through diverse mechanisms, influencing physiological activities. This paper reviews recent advances in EMT, the role of different hybrid states in tumor progression, and the important role of miRNAs in EMT. Furthermore, it explores the relationship between miRNA-based EMT therapies and their implications for clinical practice, discussing how ongoing developments may enhance therapeutic outcomes.
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