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Updated: May 6, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
Experimental Therapeutics in Parkinson's Disease: A Review
Priti Gros1, Laura Armengou Garcia2, Susan H Fox2
1Edmond J. Safra Program in Parkinson's Disease, Movement Disorders Clinic, Krembil Brain Institute, UHN Toronto Western Hospital, 399 Bathurst Street MC7 421, Toronto, Ontario M5T 2S8, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Abstract:
The prevalence and burden of Parkinson's disease (PD) is rising. Motor symptoms are primarily treated with dopamine replacement, although with limitations and complications over time. Advances in PD research include new drug candidates and innovative repurposing of existing drugs targeting various molecular mechanisms. Several agents are under Food and Drug Administration review, highlighting the dynamic progress in the field. This review summarizes the latest experimental therapies for PD, including both motor and nonmotor symptom treatments. A total of 147 studies were included, examining new dopaminergic and nondopaminergic therapies, innovative drug formulations, and approaches to managing motor complications and nonmotor symptoms.
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