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Published on: July 24, 2016
Infectious Encephalitis: A Persistent Clinical Challenge
Armghan Azhar Azhar Munir1, Margaret McCort1, Daniel A Burack1
1Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, 3411 Wayne Avenue, Suite #4H, Bronx, NY 10467, USA.
Abstract:
Encephalitis is a serious neurologic condition that frequently results in long-term neurologic complications. Effective management in adults with suspected infectious encephalitis involves testing the cerebrospinal fluid for common pathogens, including herpes simplex virus-1, varicella-zoster virus, enteroviruses, and West Nile virus. Early initiation of high-dose intravenous acyclovir is recommended. Epidemiologic clues and immune status of the host should be considered when attempting to identify the cause of encephalitis. When no cause is identified, next-generation sequencing or a brain biopsy may be warranted. Further research should focus on developing new therapeutic options for this challenging clinical syndrome.
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