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The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
Published on: May 16, 2016
Combination of the microalga Pavlova sp. OPMS 30543 with diclofenac attenuates hyperalgesia in adjuvant-induced
Wataru Nemoto1, Kotaro Yamada2, Ruka Kobayashi1
1Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Abstract:
Marine microalgae, such as Pavlova spp, are known to produce bioactive compounds and have been extensively studied as natural resources with anti-inflammatory properties. Among several Pavlova spp, OPMS 30543 (Pav) has recently been found to contain a high fucoxanthin content. In this study, we aimed to evaluate the effects of Pav treatment on hyperalgesia using a mouse model of adjuvant-induced arthritis (AIA), which was established by injecting complete Freund's adjuvant. Pav alone did not suppress the hyperalgesia observed in AIA mice. However, combined with low-dose diclofenac (DFC; 0.1 mg/kg) resulted in marked analgesia. In AIA mice, the activation of excitatory neurons was observed in the spinal cord; however, this activation was suppressed by the combination of Pav and DFC. These findings suggest that Pav enhances the analgesic effect of DFC in a mouse arthritis-associated hyperalgesia, and may aid in the development of improved strategies for inflammatory pain management.
