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Analysis of risk factors of intracranial infection after microvascular decompression

Zhifei Guo1, Xiangyu Zhang1, Bing Zhao2

  • 1Department of Neurosurgery, Cerebral Vascular Disease Research Centre, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.

Scientific Reports
|April 4, 2025
PubMed

Insights

Intracranial infection after microvascular decompression (MVD) is common. Longer operation duration and mastoid air cell breach are key risk factors for post-MVD infection.

Area of Science:

  • Neurosurgery
  • Infectious Disease Epidemiology

Background:

  • Intracranial infection is a significant complication following microvascular decompression (MVD).
  • Identifying risk factors for post-MVD intracranial infection is crucial for prevention and management.

Purpose of the Study:

  • To identify independent risk factors for intracranial infection after MVD.
  • To establish a predictive model for post-MVD intracranial infection.

Main Methods:

  • Retrospective analysis of clinical data from 154 patients undergoing MVD.
  • Univariate and multivariate logistic regression analyses to identify risk factors.
  • Receiver Operating Characteristic (ROC) curve analysis for predictive value.

Main Results:

  • The overall incidence of intracranial infection was 15.6% (24/154 patients).
  • Univariate analysis identified gender, operation duration, CSF leakage, mastoid air cell breach, implants, and antibiotic use as risk factors.
  • Multivariate analysis revealed operation duration and mastoid air cell breach as independent risk factors.
  • Combined prediction using operation duration and mastoid air cell breach showed high predictive value (AUC=0.807).

Conclusions:

  • Prolonged operation duration and mastoid air cell breach are independent risk factors for intracranial infection post-MVD.
  • A combined predictive model incorporating these factors offers significant value in assessing the risk of intracranial infection following MVD.
Keywords:
CraniotomyIntracranial infectionMicrovascular decompressionRisk factors

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