Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

78
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
78
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

131
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
131
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

57
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
57
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

70
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
70
Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

79
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
79
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

54
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
54

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical impact of opioid use in patients with urothelial carcinoma treated with pembrolizumab: a single center retrospective study.

Immunotherapy·2026
Same author

Soft palate leukoplakia as an endoscopic finding associated with esophageal squamous cell carcinoma.

Esophagus : official journal of the Japan Esophageal Society·2026
Same author

Prognostic Significance of Pretreatment Blood-Based Biomarkers in Penile Cancer: A Multicenter Retrospective Study in Japan.

International journal of urology : official journal of the Japanese Urological Association·2026
Same author

Peranal Endoscopic Myectomy for Lower Rectal Lesions with Severe Fibrosis: A Retrospective Study.

Digestive diseases and sciences·2026
Same author

Retrograde-antegrade rendezvous recanalization for complete cervical esophageal obstruction after chemoradiotherapy: a novel organ-preserving approach.

Endoscopy·2026
Same author

Recurrence Risk Stratification in Clear Cell Renal Cell Carcinoma Using TNM 2017 and WHO/ISUP Grade.

Anticancer research·2026

Related Experiment Video

Updated: Jun 16, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.3K

Post-endoscopy esophageal squamous cell carcinoma with invasion of the muscularis mucosa or deeper detected in

Daiki Kitagawa1,2, Ryu Ishihara3, Shunsuke Yoshii1

  • 1Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, 541-8567, Japan.

Esophagus : Official Journal of the Japan Esophageal Society
|April 5, 2025
PubMed
Summary

Post-endoscopic resection of esophageal squamous cell carcinoma (ESCC), advanced subsequent lesions (PEEALs) show a distinct marginal elevation feature. Careful surveillance endoscopy is crucial for detecting these PEEALs.

Keywords:
Diagnostic techniquesDigestive systemEndoscopyEsophageal neoplasmsEsophageal squamous cell carcinomaGastrointestinal

More Related Videos

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

8.5K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

393

Related Experiment Videos

Last Updated: Jun 16, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.3K
ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

8.5K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

393

Area of Science:

  • Gastroenterology
  • Oncology
  • Endoscopy

Background:

  • Surveillance endoscopy is recommended after endoscopic resection of esophageal squamous cell carcinomas (ESCCs).
  • Advanced subsequent ESCCs invading the muscularis mucosa (MM) or deeper can be detected during surveillance.
  • Understanding the features of these advanced lesions is critical for effective patient management.

Purpose of the Study:

  • To clarify the clinicopathological and endoscopic features of advanced subsequent ESCCs detected during surveillance endoscopy.
  • To compare these advanced lesions with non-advanced subsequent ESCCs and primary ESCCs.

Main Methods:

  • A single-center retrospective study identified subsequent ESCCs after endoscopic resection.
  • Post-endoscopy esophageal advanced lesions (PEEALs) were defined as ESCCs invading MM or deeper, detected within 24 months of prior endoscopy.
  • Two studies compared PEEALs with non-advanced lesions and primary lesions regarding clinicopathological and endoscopic characteristics.

Main Results:

  • Study 1 analyzed 307 subsequent ESCCs, with 20 PEEALs and 287 non-advanced lesions.
  • PEEALs showed a higher prevalence of marginal elevation morphology (60%) compared to non-advanced lesions.
  • Study 2 found pT1a-MM PEEALs were smaller (median 10 mm vs. 30 mm) and had more marginal elevation (53.3% vs. 10.1%) than primary lesions.

Conclusions:

  • Marginal elevation is a specific feature distinguishing post-endoscopy esophageal advanced lesions (PEEALs).
  • Careful observation during surveillance endoscopy is recommended to detect these advanced subsequent ESCCs.
  • Early identification of PEEALs can potentially improve outcomes after ESCC treatment.