Advancing Upper Gastrointestinal Cancer Detection: A Single-Center Pilot Study Exploring the Potential of Electrical
Hadi Mokhtari Dowlatabad1, Reihane Mahdavi1,2, Seyed Rouhollah Miri2,3
1Nano Bioelectronics Devices Lab (NBEL), Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box, Tehran, 14399-57131, Iran.
Digestive Diseases and Sciences
|April 5, 2025
Summary
A new Electrical Endoscopic Mass Characterizer (EEMC) aids in early gastrointestinal cancer detection. This device improves diagnostic accuracy during endoscopy, reducing misdiagnoses of high-risk lesions.
Area of Science:
- Gastroenterology
- Medical Devices
- Oncology
Background:
- Standard endoscopic evaluation carries risks of misdiagnosis for gastrointestinal (GI) cancers.
- Early detection of GI cancer masses is crucial for effective treatment and improved patient outcomes.
Purpose of the Study:
- To introduce a novel real-time intra-endoscopic electrical diagnostic probe for discriminating high-risk GI lesions.
- To enhance the accuracy of early-stage GI cancer detection during routine endoscopic procedures.
Main Methods:
- Development and utilization of a modified endoscopic biopsy forceps as a non-invasive diagnostic probe.
- Real-time electrical characterization of lesions during endoscopic examination.
Main Results:
- The Electrical Endoscopic Mass Characterizer (EEMC) demonstrated high performance in a study of 52 patients.
- The device achieved 94.7% sensitivity, 93.9% specificity, and 94.2% accuracy in identifying high-risk lesions.
- Results were validated against histopathological evaluations, showing statistical significance (p < 0.01).
Conclusions:
- The EEMC serves as a precise complementary tool for endoscopic evaluations.
- It can significantly improve the accuracy of early-stage GI cancer detection.
- The device integrates seamlessly into routine procedures without causing interruptions.
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