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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Discovery of the first-in-class DOT1L PROTAC degrader

Hyerin Yim1, Renhong Sun1, Zhongli Xu1

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.

European Journal of Medicinal Chemistry
|April 5, 2025
PubMed
Abstract

Keywords:
DOT1LDegraderLeukemiaMethyltransferasePROTAC

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