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Role of brain-derived neurotrophic factor in frailty: From mechanisms to interventions.

Yuanchun Xu¹, Ziyan Liu², Jiao Xu¹

¹Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie

|April 5, 2025

Summary

Frailty, a condition increasing disability and mortality risk, may be reversible. Brain-derived neurotrophic factor (BDNF) shows potential as a biomarker for early detection and intervention in frail individuals.

Keywords:

BDNF Frailty Indicators Therapeutics TrkB

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Area of Science:

Gerontology
Neuroscience
Biomarkers

Background:

Frailty is a prevalent geriatric syndrome associated with adverse health outcomes like disability, falls, and mortality.
Early detection and intervention are crucial for managing frailty, as it shows potential for reversibility.
Identifying key biological regulators may yield effective biomarkers for frailty detection and treatment.

Purpose of the Study:

To explore the mechanistic links between frailty indicators and brain-derived neurotrophic factor (BDNF).
To review current strategies for modulating BDNF levels in both healthy and pathological states.
To identify potential therapeutic targets for frailty based on BDNF's role.

Main Methods:

Literature review focusing on the association between frailty markers and BDNF.
Analysis of studies investigating BDNF's involvement in biological processes relevant to frailty.
Synthesis of research on interventions affecting BDNF in various health conditions.

Main Results:

BDNF is implicated in diverse biological processes, including cognition and inflammation, which are relevant to frailty.
Evidence suggests a connection between BDNF levels and various frailty indicators.
Existing methods to modulate BDNF offer potential avenues for frailty intervention.

Conclusions:

BDNF represents a promising target for understanding and potentially treating frailty.
Further research into BDNF modulation could lead to novel strategies for preventing or reversing frailty.
Targeting BDNF may offer a pathway to improve health outcomes in the aging population.