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Related Experiment Video

Updated: May 16, 2025

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Recent advances in bioreceptor-based sensing for extracellular vesicle analysis.

Myoung Gyu Kim¹, Soo Min Ryu², Yong Shin³

¹Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei Ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Biosensors & Bioelectronics

|April 5, 2025

Summary

Bioreceptor-based biosensors offer sensitive and specific detection of extracellular vesicles (EVs) for improved disease diagnostics. These advanced tools overcome challenges posed by EV heterogeneity, enabling precise characterization and real-time analysis.

Keywords:

Biomarker analysis Bioreceptor-based biosensing Diagnostics Extracellular vesicles

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Last Updated: May 16, 2025

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

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Published on: March 17, 2023

Extracellular Vesicle Uptake Assay via Confocal Microscope Imaging Analysis

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Published on: February 14, 2022

Rapid Fluorescence-based Characterization of Single Extracellular Vesicles in Human Blood with Nanoparticle-tracking Analysis

Rapid Fluorescence-based Characterization of Single Extracellular Vesicles in Human Blood with Nanoparticle-tracking Analysis

Published on: January 7, 2019

Area of Science:

Biotechnology
Nanotechnology
Biomedical Engineering

Background:

Extracellular vesicles (EVs) are crucial biomarkers for disease diagnostics due to their cargo reflecting cellular origin.
EV heterogeneity (size, composition, source) poses challenges for reliable detection and analysis.
Conventional methods like ultracentrifugation have limitations.

Purpose of the Study:

To review advances in bioreceptor-based biosensor technologies for EV detection and characterization.
To highlight how these biosensors address limitations of conventional EV analysis.
To showcase the potential of biosensors in EV research and diagnostics.

Main Methods:

Utilizing bioreceptors such as antibodies, aptamers, peptides, lectins, and molecularly imprinted polymers.
Targeting specific EV surface markers (proteins, lipids, glycans) for precise detection.
Employing biosensor platforms for sensitive, specific, multiplexed, and real-time EV analysis.

Main Results:

Bioreceptor-based biosensors demonstrate high sensitivity and specificity in EV detection.
These technologies enable precise characterization of EV subpopulations.
Biosensors allow for real-time analysis while maintaining EV structural integrity.

Conclusions:

Bioreceptor-based biosensors represent a significant advancement in extracellular vesicle research.
These technologies offer transformative potential for disease diagnostics and therapeutic monitoring.
The integration of biosensing tools and bioreceptors paves the way for novel diagnostic innovations.