Phenoxybiphenyl derivatives from an endophyte, Neohendersonia kickxii
Reo Takahashi1, Zulfikar1, Mayuka Hakozaki2
1Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.
Abstract:
Three undescribed phenoxybiphenyl, neohenbiphenylols A (1), B (2) and C (3) along with known of diphenyl ethers 4, and 5, and dibenzofuran 6 were isolated from the endophyte Neohendersonia kickxii RT-749. The structures of these undescribed compounds, including their absolute configurations, were elucidated by analyses of NMR, UV, IR, HRESITOFMS, and ECD data. Compounds 1-3 showed cytotoxicity against human promyelocytic leukemia (HL60) cells with IC50 values of 3.7, 4.3 and 7.3 μM, respectively, and antimicrobial activity against Bacillus subtilis with an MIC value of 25 μgmL-1.
Related Concept Videos
Nucleophilic Aromatic Substitution: Elimination–Addition
Benzene to Phenol via Cumene: Hock Process


![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)