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Related Experiment Video

Updated: May 16, 2025

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

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Oxyntomodulin - past, present and future.

Jens Juul Holst¹, Mette M Rosenkilde²

¹The NovoNordisk Foundation Center for Basic Metabolic Research, Denmark; Department of Biomedical Sciences, the Panum institute, University of Copenhagen, Denmark.

|April 5, 2025

Summary

Oxyntomodulin, a gut peptide, shows promise for treating metabolic dysfunction-associated steatotic liver disease (MASLD). Its dual action inspires new glucagon-GLP-1 co-agonists for weight loss and liver fat reduction.

Keywords:

Co-agonists GLP-1 Glicentin Glucagon Weight loss

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Area of Science:

Endocrinology
Gastroenterology
Metabolic Diseases

Background:

Glucagon's gastrointestinal origin suggested by L-cells containing glucagon-like immunoreactivity.
Presence of glicentin and oxyntomodulin peptides, both containing the full glucagon sequence, in L-cells.
Oxyntomodulin, a glicentin fragment, interacts with glucagon and GLP-1 receptors, influencing appetite and food intake.

Purpose of the Study:

To explore the therapeutic potential of oxyntomodulin and its derivatives.
To investigate the efficacy of glucagon-GLP-1 co-agonists in treating metabolic disorders.
To assess the impact of these co-agonists on weight loss and hepatic steatosis.

Main Methods:

Analysis of peptide interactions with glucagon and GLP-1 receptors.
Human studies on oxyntomodulin's effects on appetite and food intake.
Clinical development of long-acting glucagon-GLP-1 co-agonists.

Main Results:

Oxyntomodulin demonstrated appetite and food intake inhibition in humans.
Glucagon-GLP-1 co-agonists achieve additive weight loss.
Co-agonists stimulate hepatic lipid metabolism, showing effectiveness in hepatic steatosis.

Conclusions:

Oxyntomodulin's properties have inspired the development of promising glucagon-GLP-1 co-agonists.
These co-agonists offer a dual therapeutic approach for weight management and metabolic health.
Potential for effective treatment of metabolic dysfunction-associated steatotic liver disease (MASLD).