Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition).

Hepatobiliary surgery and nutrition·2026
Same author

Near-infrared II fluorescence imaging of PD-L1 and VEGF for assessing and early prediction of "T+A" therapeutic responsiveness in hepatocellular carcinoma.

Materials today. Bio·2026
Same author

Transcriptomic profiling of oocyte maturation in allotetraploid hybrid fish and identification of HSD17b12 mediating DHP synthesis.

The Journal of steroid biochemistry and molecular biology·2026
Same author

Quercetin Induces Macrophage Polarization through PI3K-AKT Pathway in Atherosclerosis: Network Pharmacology, Molecule Docking and in vitro Analysis.

Iranian journal of pharmaceutical research : IJPR·2026
Same author

HERV2365 upregulates FGF1 expression by sponging miR-326 to promote the progression of intrahepatic cholangiocarcinoma.

iScience·2026
Same author

Cynaroside reduces neutrophil extracellular trap formation and disease severity in a mouse model of asthma by inhibiting the COX-2/TNF-alpha/NF-kB axis.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same journal

Association between retinal microcirculation and cardiac function: A cross-sectional study using OCTA.

Microvascular research·2026
Same journal

Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.

Microvascular research·2026
Same journal

Association of circulating biomarkers of glycocalyx injury, sirtuin 1, and NFκB p65 in individuals with type 2 diabetes and concurrent arterial hypertension.

Microvascular research·2026
Same journal

Targeting miR-10 alleviates atherosclerosis by enhancing intestinal ABCA1-mediated cholesterol efflux and repairing intestinal barrier.

Microvascular research·2026
Same journal

The effect of acute high-intensity interval exercise on microvascular function and local skeletal muscle oxygenation.

Microvascular research·2026
Same journal

RNF213 deficiency in human iPSC-derived vascular organoids captures key feature of moyamoya disease vasculopathy.

Microvascular research·2026
See all related articles

Related Experiment Video

Updated: May 16, 2025

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
07:03

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

1.4K

Increase in endothelial microparticles is negatively correlated with decrease in renal microperfusion in septic rats.

Xinjie Guo1, Jingfeng Liu1, Meili Duan1

  • 1Department of Critical Care Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing 100050, China.

Microvascular Research
|April 5, 2025
PubMed
Summary
This summary is machine-generated.

Endothelial microparticles (EMPs) correlate with reduced renal microcirculation in septic acute kidney injury (S-AKI). Contrast-enhanced ultrasound (CEUS) imaging shows potential for early S-AKI diagnosis by detecting microcirculatory changes.

Keywords:
Endothelial microparticlesKidney microcirculationRatsSepsis

More Related Videos

Intravascular Delivery of Biologics to the Rat Kidney
07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

7.5K
Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
12:48

Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery

Published on: September 12, 2015

9.7K

Related Experiment Videos

Last Updated: May 16, 2025

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
07:03

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

1.4K
Intravascular Delivery of Biologics to the Rat Kidney
07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

7.5K
Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
12:48

Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery

Published on: September 12, 2015

9.7K

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Vascular Biology

Background:

  • Endothelial dysfunction is a key factor in septic acute kidney injury (S-AKI).
  • Endothelial microparticles (EMPs) indicate endothelial damage.
  • The link between EMPs and renal microperfusion in S-AKI requires clarification.

Purpose of the Study:

  • To investigate the association between EMPs and renal microcirculatory perfusion in a rat model of S-AKI.
  • To evaluate the utility of contrast-enhanced ultrasound (CEUS) and side-stream dark-field imaging in assessing renal microperfusion.

Main Methods:

  • A cecal ligation and puncture model was used to induce S-AKI in Sprague-Dawley rats.
  • Measurements included mean arterial pressure (MAP), lactate, renal artery blood flow (RBF), and mean renal artery velocity.
  • Flow cytometry quantified EMPs; CEUS assessed cortical and medullary perfusion; side-stream dark-field imaging evaluated perfused small vessel density (PVD) and microvascular flow index (MFI).

Main Results:

  • In septic rats, EMPs and lactate levels increased, while macrohemodynamics (MAP, RBF) remained stable initially.
  • Renal microperfusion markers (cortical/medullary peak echointensity, PVD, MFI) decreased.
  • EMPs showed a negative correlation with diminished renal microcirculatory perfusion.

Conclusions:

  • EMPs are closely linked to renal microcirculatory dysfunction in S-AKI.
  • CEUS can sensitively detect renal microperfusion changes, offering earlier S-AKI indication than macrocirculatory parameters.
  • CEUS shows promise for the early diagnosis of S-AKI.