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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Exploring the relationship and diagnostic targets of seborrheic dermatitis and scalp psoriasis based on multi-omics
Li Yang1, Yunying Wang2, Yiya Zhang2
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; FuRong Laboratory, Changsha, China; CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
Abstract:
Scalp seborrheic dermatitis (SD) and psoriasis (PSO) are prevalent chronic skin conditions with overlapping clinical manifestations, especially when confined to the scalp, which complicates differential diagnosis. This study integrates transcriptomic profiling and genetic association analyses to investigate potential causal links between SD and scalp PSO. Through RNA sequencing on lesional and non-lesional scalp samples from patients with SD and scalp PSO, as well as healthy controls, we found that seborrheic dermatitis may represent a risk factor for the progression to scalp PSO. Furthermore, TGM1 and IL36RN were identified as key potential molecular targets that could differentiate seborrheic dermatitis from scalp PSO.
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