Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed identification and treatment of a cervicomedullary spinal vascular lesion following angiogram-negative, high-grade subarachnoid hemorrhage: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Oncolytic viruses enhance CAR-T activity for the treatment of pediatric diffuse midline gliomas.

Molecular therapy. Oncology·2026
Same author

Oesophageal tissue screening system for assessing the retention and mucosal absorption of biologics.

Nature biomedical engineering·2026
Same author

The Use of Deep Learning in RNA Therapeutic Development.

ACS nano·2026
Same author

Leveraging neuroscience imaging and electrophysiological assessments to decode neuron-glioma interactions.

Neuro-oncology advances·2026
Same author

Adult presentation of a vein of Galen malformation as cognitive decline in a 47-year-old multiparous female: illustrative case.

Journal of neurosurgery. Case lessons·2026

Related Experiment Video

Updated: May 16, 2025

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
08:42

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

877

Implantable systems for neurological chronotherapy.

Seung Ho Lee1, Roemer Pott Hofstede2, Adrián Noriega de la Colina3

  • 1The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Advanced Drug Delivery Reviews
|April 5, 2025
PubMed
Summary
This summary is machine-generated.

Implantable neurological systems offer precise, circadian rhythm-timed drug delivery, revolutionizing central nervous system disease treatment by bypassing the blood-brain barrier. These advanced devices enhance therapeutic efficacy while minimizing side effects for conditions like epilepsy and glioblastoma.

Keywords:
ChronotherapyCircadian rhythmsDrug deliveryImplantsNeurology/neurosurgery

More Related Videos

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue
10:18

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

44.6K
Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

15.4K

Related Experiment Videos

Last Updated: May 16, 2025

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
08:42

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

877
Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue
10:18

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

44.6K
Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

15.4K

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Pharmacology

Background:

  • Implantable systems are emerging for neurological chronotherapy, enabling precise, time-controlled drug delivery.
  • These systems align treatment with the body's circadian rhythms to optimize therapeutic outcomes for central nervous system (CNS) diseases.
  • They bypass the blood-brain barrier, achieving high local drug concentrations and reducing systemic side effects.

Purpose of the Study:

  • To review the current state of implantable neurological systems for chronotherapy.
  • To explore their applications, limitations, and potential in managing neurological diseases and disorders.
  • To highlight the advantages of time-controlled drug delivery aligned with circadian rhythms.

Main Methods:

  • Review of existing literature on implantable drug delivery systems for neurological applications.
  • Analysis of platforms like SynchroMed II and CraniUS for programmable drug delivery.
  • Examination of preclinical and clinical studies on circadian-timed drug delivery for epilepsy and glioblastoma.

Main Results:

  • Implantable systems allow for programmable drug delivery, including continuous infusion and timed bolus administration.
  • Circadian-aligned drug delivery has shown enhanced efficacy in chrono-chemotherapy and anti-epileptic treatments.
  • Platforms enable high local drug concentrations, crucial for treating CNS disorders effectively.

Conclusions:

  • Implantable neurological chronotherapy systems hold significant promise for revolutionizing CNS disease treatment.
  • Challenges include invasiveness, device longevity, synchronization complexity, and cost.
  • Further development is needed to fully realize the potential of these advanced therapeutic platforms.