Development of polylactic acid microneedles for enhanced transdermal delivery of desmopressin peptides: A...

Addressing the challenges associated with traditional injection therapies, this research marks a significant advancement in personalized and targeted therapeutic interventions, offering improved efficacy, convenience, and safety for patients undergoing peptide-based treatments. This article presents a research study on the development and assessment of polylactic acid (PLA) microneedles for enhancing the delivery of proteins and peptides, mainly focusing on the transdermal administration of desmopressin. Using simulations with COMSOL multiphysics software, it has been shown that PLA microneedles have excellent durability and controlled drug delivery capabilities, which promise efficient and patient-friendly transdermal drug delivery applications. Computational modeling results highlighted the dynamic behavior of desmopressin flow within the microneedle system, emphasizing accelerated drug transport capabilities. The utilization of dissolving microneedles in this study underscores the potential of microneedle technology as a promising solution for enhancing transdermal drug permeation, particularly for hydrophilic and macromolecular substances like proteins and peptides, thus opening new avenues for effective drug delivery systems.