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[11C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau
Aisling M Chaney1, Brian A Gordon1
1Department of Radiology, Washington University, St. Louis, MO, USA.
Abstract:
Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [11C]ER176, a novel translocator protein 18 kDa (TSPO)-positron emission tomography (PET) tracer overcoming genotype-related binding issues, to show increased inflammation in early-onset AD, with patterns aligning more closely with tau pathology than amyloid deposition or atrophy.
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