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Interoception and aging
Erliang Li1, Wenjing Niu2, Chao Lu3
1Honghui Hospital, Xi'an Jiaotong University, Xi'an 710000, China; Xi'an Key Laboratory of Pathogenesis and Precision Treatment of Arthritis, Xi'an 710000, China.
Ageing Research Reviews
|April 6, 2025
Summary
This study redefines interoception and explores its crucial role in maintaining body homeostasis. It investigates the complex interplay between interoception and aging, proposing new biomarkers for interoception-aging interactions.
Area of Science:
- Physiology
- Neuroscience
- Gerontology
Background:
- Interoception, the perception of internal bodily states, is vital for homeostasis.
- Existing definitions of interoception do not encompass the full scope of related research.
- The interaction between interoception and the aging process is not well understood.
Purpose of the Study:
- To propose an updated definition of interoception.
- To examine the role of interoception in maintaining body homeostasis.
- To comprehensively analyze interoceptive-aging interactions and their implications.
Main Methods:
- Literature review and synthesis of existing research on interoception and aging.
- Analysis of physiological, neural, endocrine, and behavioral mechanisms.
- Exploration of potential biomarkers for interoception-aging.
Main Results:
- An updated definition of interoception is proposed to better reflect current research.
- Interoception plays a significant role in regulating body homeostasis.
- Arachidonic acid metabolites show potential as biomarkers for interoception-aging.
Conclusions:
- Understanding interoceptive-aging interactions offers a novel perspective on aging mechanisms.
- This research provides a theoretical basis for developing anti-aging strategies.
- Further investigation into interoception and aging is crucial for healthspan.
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