Integrating Aversive Memories in the Basolateral Amygdala

Decades of research have established a critical role of the basolateral complex of the amygdala (BLA) in the encoding and storage of aversive memories. Much of this work has utilized Pavlovian fear conditioning procedures in which animals experience a single aversive event. Although this effort has produced great insight into the neural mechanisms that support fear memories for an isolated aversive experience, much less is known about how amygdala circuits encode and integrate multiple emotional experiences. The emergence of methods to label and record neuronal ensembles over days allows a deeper understanding of how amygdala neurons encode and integrate distinct aversive episodes over time. Here, we review evidence that the BLA is an essential site for the persistent storage of long-term fear memory. As a long-term storage site for fear memory, a challenge for encoding multiple fear memories is the mechanisms by which BLA neurons allocate, integrate, and discriminate distinct experiences from one another. In this review, we discuss the historical evidence supporting the BLA as a critical site for long-term memory storage, as well as new evidence that stems from technological advances that allow researchers to simultaneously study the encoding and storage of multiple memory traces, including recent versus remote experiences. We explore the possibility that dysfunction in ensemble coding schemes contributes to the pathophysiology of posttraumatic stress disorder and argue that future studies should place increased emphasis on potential subregional differences in memory coding schemes in the amygdala to deepen our understanding of both normal and pathological emotional memory.