Fate of mitral regurgitation after transcatheter closure of patent ductus arteriosus: single centre study

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Gayathri Bhuvaneswaran Kartha1, Shruti Irene Varghese1, Jesu Krupa1

  • 1Department of Cardiology, Christian Medical College, Vellore, India.

Indian Heart Journal
|April 6, 2025
PubMed

Insights

Transcatheter patent ductus arteriosus closure (PDA-DC) effectively treats hemodynamically significant PDA and associated mitral regurgitation. Most patients experienced symptomatic improvement and reduced mitral regurgitation severity after PDA-DC.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Cardiovascular Surgery

Background:

  • Patent ductus arteriosus (PDA) is often linked with mitral regurgitation (MR).
  • Treatment options include surgical PDA ligation or transcatheter PDA closure (PDA-DC).
  • The management of MR following PDA-DC requires further investigation.

Purpose of the Study:

  • To evaluate the impact of transcatheter PDA closure (PDA-DC) on mitral regurgitation (MR) in patients with PDA and significant MR.

Main Methods:

  • Retrospective review of electronic health records from 2013-2023.
  • Identification of 14 eligible patients with PDA and significant MR.
  • Analysis of MR severity and patient symptoms post-PDA-DC.

Main Results:

  • All 14 patients (100%) showed symptomatic improvement after PDA-DC.
  • A significant reduction in MR severity was observed in 12 patients (85.7%).

Conclusions:

  • Transcatheter PDA closure is an effective treatment for PDA with associated significant MR.
  • PDA-DC can lead to substantial improvement in MR severity, potentially obviating the need for subsequent MR treatment.
Keywords:
Mitral regurgitationPatent ductus arteriosusTranscatheter PDA closure

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