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Updated: May 16, 2025
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
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Hypopigmented Junctional BAP1-Inactivated Melanocytoma: A Paradigm Shift.
Ali Gunesch1, Iwei Yeh2, Timothy McCalmont3
1Oregon Health & Science University, School of Medicine, Portland, Oregon, USA.
Journal of Cutaneous Pathology
|April 6, 2025
Summary
This study details a rare case of multiple BAP1-inactivated melanocytomas with hypopigmented features. Genetic analysis revealed identical BAP1 mutations across lesions, with one also showing NF1 mutations.
Area of Science:
- Dermatopathology
- Oncology
- Genetics
Background:
- BRCA1-associated protein 1 (BAP1)-inactivated melanocytomas are increasingly characterized.
- Previous reports have not widely documented multiple BAP1-inactivated melanocytomas presenting with hypopigmentation.
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