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Aortic thrombi microstructure through contrast-enhanced X-ray microtomography.

Joris Léonet1, Jérôme Vicente2, Mariangela De Masi-Jacquier1,3

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Summary
This summary is machine-generated.

Intraluminal thrombus (ILT) in abdominal aortic aneurysms has varying porosity. This 3D micro-CT study reveals interconnected pores in the luminal layer, potentially facilitating cell passage and contributing to disease progression.

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Biological porous mediaMicro-CTMicrostructureVirtual tomography

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Vascular Biology

Background:

  • Intraluminal thrombus (ILT) is a porous structure within abdominal aortic aneurysms (AAAs).
  • The role of ILT morphology and porosity in AAA progression and rupture is not fully understood.
  • Previous 2D studies lack the resolution to accurately characterize ILT's complex porous network.

Purpose of the Study:

  • To quantitatively analyze the 3D morphology of ILT using contrast-enhanced X-ray micro-computed tomography (micro-CT).
  • To validate micro-CT image segmentation using virtual tomography.
  • To investigate the relationship between ILT porosity, pore size, and potential cellular transport.

Main Methods:

  • Contrast-enhanced X-ray micro-computed tomography (micro-CT) for high-resolution 3D imaging of ILT.
  • Development and application of a virtual tomography-based validation pipeline for image segmentation.
  • Quantitative analysis of porosity, pore size distribution, and pore interconnectivity across ILT layers.

Main Results:

  • Porosity decreases from the luminal to the abluminal layer of the ILT.
  • Pore diameters are similar across layers, but interconnectivity is higher in the luminal region.
  • Interconnected pore sizes (15-20 µm) suggest facilitated cell passage through the ILT.
  • Observed pore anisotropy across the ILT thickness.

Conclusions:

  • 3D micro-CT provides reliable quantitative morphological data for ILT.
  • The porous structure of ILT, particularly the luminal layer, may play a role in AAA pathogenesis.
  • Further investigation into ILT permeability is warranted to confirm its contribution to aortic wall hypoxia.