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Construction of ubiquitination-related risk model for predicting prognosis in lung adenocarcinoma

  • 0School of Disaster and Emergency Medicine, Faculty of Medicine, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, China.
Scientific Reports +

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April 6, 2025

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April 6, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies a ubiquitination-related gene signature (URRS) as a prognostic biomarker for lung adenocarcinoma. Higher URRS indicates a worse prognosis and altered tumor microenvironment, aiding treatment decisions.

Area Of Science

  • Oncology
  • Molecular Biology
  • Biochemistry

Background

  • Lung adenocarcinoma (LUAD) is the most common type of lung cancer.
  • Ubiquitination, a key post-translational modification, plays a role in cancer development and progression.
  • Understanding ubiquitination's role in LUAD is crucial for improving patient outcomes.

Purpose Of The Study

  • To investigate the association between ubiquitination and lung adenocarcinoma.
  • To develop a novel ubiquitination-related gene signature (URRS) for predicting LUAD prognosis.
  • To explore the correlation between URRS and tumor biological features, including immune infiltration and chemotherapy response.

Main Methods

  • Utilized TCGA-LUAD cohort for training and 6 external cohorts for validation.
  • Employed unsupervised clustering, Cox regression, Random Survival Forests, and LASSO Cox regression to identify ubiquitination-related genes (URGs).
  • Calculated URRS based on gene expression and assessed its correlation with prognosis, immune infiltration, tumor mutation burden (TMB), tumor neoantigen load (TNB), PD1/L1 expression, and drug sensitivity.

Main Results

  • A four-gene signature (DTL, UBE2S, CISH, STC1) was identified, forming the URRS.
  • Higher URRS was significantly associated with poorer prognosis in LUAD patients (HR=0.54, p<0.001), validated in external cohorts.
  • High URRS group exhibited increased PD1/L1 expression, TMB, TNB, and tumor microenvironment (TME) scores, with lower sensitivity to chemotherapy drugs.

Conclusions

  • The developed ubiquitination-based signature (URRS) serves as a robust prognostic biomarker for lung adenocarcinoma.
  • URRS can help evaluate biological characteristics, predict treatment response, and guide therapeutic strategies for LUAD patients.
  • This signature offers potential for personalized medicine approaches in lung adenocarcinoma management.

Keywords:

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